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Title: The effect of a novel dinuclear platinum complex with berenil and 2-picoline ligands on growth of human breast cancer cells. Author: Bielawski K, Bielawska A, Popławska B, Surazyński A, Czarnomysy R. Journal: Acta Pol Pharm; 2010; 67(6):609-14. PubMed ID: 21229875. Abstract: Evaluation of the cytotoxicity of a novel dinuclear platinum(II) complex of formula Pt2(2-picoline)4(berenil)2 employing a MTT assay and inhibition of [3H]thymidine incorporation into DNA in both MDA-MB-231 and MCF-7 breast cancer cells demonstrated that the complex was more potent anti-proliferative agent than cisplatin. Data from the ethidium displacement assay indicated that the complex showed specificity for AT base pairs of DNA. Our study showed that Pt2(2-picoline)4(berenil), was a potent catalytic inhibitor of topoisomerase II in opposition to cisplatin.[Abstract] [Full Text] [Related] [New Search]