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  • Title: Role of hemopoietic precursors of various classes in the effect of granulocyte colony-stimulating factor on hemopoiesis during cytostatic-induced myelosuppression.
    Author: Dygai AM, Skurikhin EG, Pershina OV, Andreeva TV, Khmelevskaya ES, Minakova MJ.
    Journal: Bull Exp Biol Med; 2010 Oct; 149(4):416-20. PubMed ID: 21234432.
    Abstract:
    Experiments were performed on the model of cyclophosphamide-induced myelosuppression. We showed that regeneration of the granulocytic hemopoietic stem is related to activation of multipotent, granulocyte-erythroid-macrophage-megakaryocyte, and granulocyte-macrophage precursors. The division and maturation of granulocyte colony-forming cells and significant decrease in the number of these cells in the bone were suppressed under these conditions. The granulocytopoiesis-stimulating effect of granulocyte CSF during myelosuppression was associated with an increase in functional activity of multipotent and granulocyte-erythroid-macrophage-megakaryocyte precursors (primarily of differentiation). In the period of regeneration, this effect was attributed to activity of granulocyte precursors.
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