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  • Title: Neuroprotective effects of immobilized granulocyte colony-stimulating factor and hyaluronidase.
    Author: Andreeva TV, Vereshagin EI, Ermakova NN, Madonov PG, Pershina OV, Skurikhin EG, Zjuzkov GN, Minakova MJ, Khmelevskaya ES, Dygai AM.
    Journal: Bull Exp Biol Med; 2010 Oct; 149(4):421-4. PubMed ID: 21234433.
    Abstract:
    Neuroprotective activity of immobilized granulocyte CSF (nanotechnology with electron-beam synthesis) and hyaluronidase was studied on the model of posthypoxic encephalopathy. Oral administration of immobilized granulocyte CSF had no effect on manifestations of posthypoxic psychoneurological disorders in animals. Combined treatment with immobilized granulocyte CSF and hyaluronidase prevented impairment of orientation and exploratory behavior and development of amnesia in mice with hypoxic injury.
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