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  • Title: Immobilized carbonic anhydrase in a membrane lung for enhanced CO2 removal.
    Author: Salley SO, Song JY, Whittlesey GC, Klein MD.
    Journal: ASAIO Trans; 1990; 36(3):M486-90. PubMed ID: 2123640.
    Abstract:
    The potential use of carbonic anhydrase (CA), immobilized within membrane lungs, to accelerate the removal of CO2 from blood was investigated. Using a variation on the technique of Chang, 500 micrograms/mL of CA was encapsulated in 5-20 microns cellulose nitrate microcapsules which were then immobilized onto a 0.1 m2 silicone rubber membrane. Using an in vitro test circuit, 0.68 mmol/m2/min of CO2 was removed from venous blood through an untreated membrane at steady state. With the CA-immobilized membrane, CO2 removal was enhanced to 1.09 mmol/m2/min. This technique has the potential of greatly improving the CO2 efficiency of commercial membrane lungs for ECCOR.
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