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  • Title: Explicit analytic approximations for time-dependent solutions of the generalized integrated Michaelis-Menten equation.
    Author: Goličnik M.
    Journal: Anal Biochem; 2011 Apr 15; 411(2):303-5. PubMed ID: 21241654.
    Abstract:
    Various explicit reformulations of time-dependent solutions for the classical two-step irreversible Michaelis-Menten enzyme reaction model have been described recently. In the current study, I present further improvements in terms of a generalized integrated form of the Michaelis-Menten equation for computation of substrate or product concentrations as functions of time for more real-world, enzyme-catalyzed reactions affected by the product. The explicit equations presented here can be considered as a simpler and useful alternative to the exact solution for the generalized integrated Michaelis-Menten equation when fitted to time course data using standard curve-fitting software.
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