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  • Title: p38/MAPK inhibitor modulates the expression of dorsal horn GABA(B) receptors in the spinal nerve ligation model of neuropathic pain.
    Author: Wu J, Xu Y, Pu S, Jiang W, Du D.
    Journal: Neuroimmunomodulation; 2011; 18(3):150-5. PubMed ID: 21242699.
    Abstract:
    BACKGROUND: Neuropathic pain is one of the most challenging clinical problems due to a lack of understanding the mechanisms. Recent studies have suggested that activated microglia in spinal cord may play a vital role in nerve injury-induced neuropathic pain, but the exact mechanisms have not been fully determined. METHODS: First, we investigated the changes of dorsal horn GABA(B) receptor 1 (R1) expression in spinal nerve ligation rats. Second, we explored whether activated microglia contributed to such neuron changes by intrathecal administration of the p38 inhibitor, SB203580. RESULTS: In this study, we found a dynamic change of GABA(B)R1a protein expression after spinal nerve ligation, and the peripheral nerve injury-induced downregulation of GABA(B)R1a expression in the spinal dorsal horn could be prevented by intrathecal administration of a p38/MAPK inhibitor SB203580. CONCLUSIONS: Our results provide valuable information for a better understanding of neuropathic pain and may contribute to developing effective treatments in future studies.
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