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  • Title: Treatment of psychogenic polydipsia with acetazolamide: a report of 5 cases.
    Author: Takagi S, Watanabe Y, Imaoka T, Sakata M, Watanabe M.
    Journal: Clin Neuropharmacol; 2011; 34(1):5-7. PubMed ID: 21242740.
    Abstract:
    OBJECTIVE: Psychogenic polydipsia occurs frequently in patients with chronic psychiatric illness and is often unmanageable. We herein report 5 patients in whom acetazolamide was trialed for this symptom. METHODS: We encountered a case in which polydipsia improved with incidental administration of acetazolamide. We then used this treatment for 4 additional cases of treatment-resistant psychogenic polydipsia, some of which were accompanied by hyponatremia. RESULTS: Acetazolamide improved polydipsia and/or hyponatremia in 4 of the 5 cases. This treatment was well tolerated and allowed 3 of the patients to permanently leave isolation. CONCLUSION: Acetazolamide appears to have a beneficial effect in psychogenic polydipsia.
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