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  • Title: Leflunomide use in a cytomegalovirus infection of a patient with dermatomyositis.
    Author: Orden AO, Chuluyan JC, Colombini AC, Barbera RF.
    Journal: Rheumatol Int; 2012 Jan; 32(1):273-5. PubMed ID: 21243491.
    Abstract:
    Human cytomegalovirus (CMV) is responsible for significant morbidity and mortality in immunocompromised populations, such as those suffering from dermatomyositis (DM). We present here a case study of a DM patient undergoing methotrexate treatment who presents with weakness, myalgia, elevated levels of hepatic transaminases and serological markers of CMV primo-infection. The antiviral activity of leflunomide against CMV was described recently. The use of leflunomide as an immunomodulator may have contributed to the satisfactory evolution of the treatment for a symptomatic CMV infection in an immunocompromised patient, since the typical treatment outcome is more prolonged and with additional complications.
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