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  • Title: Use of human tissue specimens obtained by directional atherectomy to study restenosis.
    Author: Isner JM, Kearney M, Bauters C, Leclerc G, Nikol S, Pickering JG, Riessen R, Weir L.
    Journal: Trends Cardiovasc Med; 1994; 4(5):213-21. PubMed ID: 21244870.
    Abstract:
    Directional atherectomy has provided the opportunity to study the pathology of restenosis in human tissue specimens from live patients. The restenosis lesion is characterized by two distinctive features: a focus of hypercellularity, comprised of cells with phenotypic features of proliferative vascular smooth muscle cells (SMCs), and a rich, loose extracellular matrix (ECM). Analysis of restenosis lesions by in situ hybridization, immunohistochemistry, and cell culture has disclosed evidence of activated SMCs, and in many cases-particularly lesions from the peripheral vasculature-ongoing cellular proliferation. The ECM of restenosis lesions is biglycan rich and decorin poor, a finding that is associated with increased expression of transforming growth factor beta (TGF-β). While certain restenosis lesions contain foci of microangiogenesis, the pathogenetic significance of this feature remains uncertain.
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