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  • Title: [Effect of high dietary fat on the total DNA and receptor contents in rats with 7,12-dimethylbenz[A]anthracene-induced mammary carcinoma].
    Author: Noguchi M, Kumaki T, Taniya T, Koyasaki N, Miyazaki I.
    Journal: Nihon Geka Gakkai Zasshi; 1990 Oct; 91(10):1603-7. PubMed ID: 2124652.
    Abstract:
    The influences of high dietary fat on the malignant intensity and the hormone receptors of DMBA-induced mammary breast carcinoma were analyzed in female Sprague-Dawley rats. The rats were fed either a low-fat diet or high-fat diet after the DMBA administration. As the results, incidence, size, average latent period, DNA histogram, DNA index and % of S-phase fraction of tumor were significantly different between both groups. But the ER and PgR contents were not different between both groups. The results suggest that a high dietary fat could increase the malignant intensity of the tumor but does not influence the receptor contents of the tumors.
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