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  • Title: Hyrtioseragamines A and B, new alkaloids from the sponge Hyrtios species.
    Author: Takahashi Y, Iinuma Y, Kubota T, Tsuda M, Sekiguchi M, Mikami Y, Fromont J, Kobayashi J.
    Journal: Org Lett; 2011 Feb 18; 13(4):628-31. PubMed ID: 21247076.
    Abstract:
    Two novel alkaloids with a furo[2,3-b]pyrazin-2(1H)-one moiety and a guanidino group, hyrtioseragamines A (1) and B (2), have been isolated from an Okinawan marine sponge Hyrtios species. The structures of 1 and 2 were elucidated on the basis of spectroscopic data and chemical conversions. Compounds 1 and 2 are the first natural products possessing a furo[2,3-b]pyrazine-related moiety.
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