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Title: Sceliphrolactam, a polyene macrocyclic lactam from a wasp-associated Streptomyces sp. Author: Oh DC, Poulsen M, Currie CR, Clardy J. Journal: Org Lett; 2011 Feb 18; 13(4):752-5. PubMed ID: 21247188. Abstract: A previously unreported 26-membered polyene macrocyclic lactam, sceliphrolactam, was isolated from an actinomycete, Streptomyces sp., associated with the mud dauber, Sceliphron caementarium. Sceliphrolactam's structure was determined by 1D- and 2D-NMR, MS, UV, and IR spectral analysis. Sceliphrolactam displays antifungal activity against amphotericin B-resistant Candida albicans (MIC = 4 μg/mL, 8.3 μM).[Abstract] [Full Text] [Related] [New Search]