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  • Title: Differential inhibitory effects of 5-bromodeoxyuridine on vaccinia and monkeypox viruses.
    Author: Yoshii T, Kono R.
    Journal: J Hyg (Lond); 1978 Oct; 81(2):171-7. PubMed ID: 212474.
    Abstract:
    Replication of vaccinia and monkeypox viruses was impeded in the presence of 5-bromodeoxyuridine (BUdR) in RL-33 cells derived from rabbit lung tissue. The different degree of inhibition was found among strains of those viruses, in which it was evident that five strains (CV-1, Lister, IHD, Dairen-I and Ikeda) of vaccinia viruses resulted in more reduced yields of infectious virus than four strains (Sen-19, Orang Utan, Copenhagen and Sierra Leone) of monkeypox viruses. There was also strain variation in BUdR sensitivity within vaccinia viruses but not in the case of monkeypox viruses.
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