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  • Title: Irreversible inhibition of D-3-aminoisobutyrate-pyruvate aminotransferase by gabaculine.
    Author: Kaneko M, Fujimoto S, Kikugawa M, Tamaki N.
    Journal: FEBS Lett; 1990 Dec 10; 276(1-2):115-8. PubMed ID: 2125004.
    Abstract:
    Gabaculine, 5-amino-1,3-cyclohexadienylcarboxylate, is an analogue of GABA and a potent irreversible inhibitor of GABA aminotransferase. However, D-3-aminoisobutyrate-pyruvate aminotransferase for which GABA was neither a substrate nor an inhibitor was also inactivated by gabaculine. The Ki for D-3-aminoisobutyrate-pyruvate aminotransferase was 8.3 x 10(-6) M, and the Kcat for its turnover was 0.31 min-1 at 25 degrees C. beta-Alanine protected the enzyme from inactivation by gabaculine, but GABA did so to much a lesser extent.
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