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Title: Single-molecule four-color FRET visualizes energy-transfer paths on DNA origami. Author: Stein IH, Steinhauer C, Tinnefeld P. Journal: J Am Chem Soc; 2011 Mar 30; 133(12):4193-5. PubMed ID: 21250689. Abstract: Fluorescence resonance energy transfer (FRET) represents a mechanism to transport light energy at the nanoscale, as exemplified by nature's light-harvesting complexes. Here we used DNA origami to arrange fluorophores that transport excited-state energy from an input dye to an output dye. We demonstrate that energy-transfer paths can be controlled on the single-molecule level by the presence of a "jumper" dye that directs the excited-state energy either to a red or to an IR output dye. We used single-molecule four-color FRET with alternating laser excitation to sort subpopulations and to visualize the control of energy transfer.[Abstract] [Full Text] [Related] [New Search]