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  • Title: Severe hypercalcemia associated with uterine leiomyoma in pregnancy.
    Author: Tarnawa E, Sullivan S, Underwood P, Richardson M, Spruill L.
    Journal: Obstet Gynecol; 2011 Feb; 117(2 Pt 2):473-476. PubMed ID: 21252794.
    Abstract:
    BACKGROUND: Uterine leiomyomas are the most common pelvic tumor, and a frequent indication of the need for gynecologic surgery. Although usually asymptomatic, life-threatening cases can occur. We present a case of critical hypercalcemia associated with a leiomyoma during pregnancy with the intention of highlighting the endocrinology of leiomyomas, features shared with malignant neoplasms, and the potential for effects on obstetric outcomes. CASE: A 32-year-old gravid woman with a large leiomyoma presented at 33 5/7 weeks of gestation with critical hypercalcemia requiring intensive care. Postpartum myomectomy cured her hypercalcemia, which was driven by parathyroid hormone-related protein (PTHrP) produced by the tumor. CONCLUSION: Obstetricians should be aware of the existence of humoral hypercalcemia related to leiomyomas and the potential effects on pregnancy.
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