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  • Title: The persistence of serological reactions following heifer vaccination with Brucella abortus strain 19 on brucellosis-free farms.
    Author: Herr S, Ehret WJ, Ribeiro LM, Chaparro F.
    Journal: J S Afr Vet Assoc; 1990 Mar; 61(1):11-3. PubMed ID: 2125318.
    Abstract:
    Of 392 heifers vaccinated between 4 and 9.5 months of age and tested at 22 months or older, 3 (0.77%) had titres in the complement fixation test of between 30 and 98 international units per millilitre. The results confirm that persistent serological reactions can be a problem even in brucellosis-free herds. To reduce the incidence of these problem reactors, it is suggested that: in clean herds the age of inoculation be reduced to 3 months of age; the age at first testing be delayed as long as possible, but be done before the heifers are 4 months pregnant, c) consideration be given to reducing the vaccine dose for all heifers from the present 4 to 12 x 10(10) to between 3 x 10(8) and 3 x 10(9) and syringes used for strain 19 vaccination be exclusively reserved for this purpose to prevent the possibility of antigenic residues acting as a booster when used for other vaccinations.
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