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  • Title: Progress in the development of bestatin analogues as aminopeptidases inhibitors.
    Author: Chen L, Teng Y, Xu W.
    Journal: Curr Med Chem; 2011; 18(7):964-76. PubMed ID: 21254977.
    Abstract:
    Aminopeptidases play essential roles in protein maturation, activation, and stability as well as in the degradation and regulation of hormonal and nonhormonal peptides that can serve as important enzyme targets for drug design. This review will focus on an effective inhibitor of aminopeptidases, bestatin, including work to find better inhibitors in the past three decades that has sought to optimize bestatin and prospective developments in bestatin optimization in the future.
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