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  • Title: Towards biochemical filters with a sigmoidal response to pH changes: buffered biocatalytic signal transduction.
    Author: Pita M, Privman V, Arugula MA, Melnikov D, Bocharova V, Katz E.
    Journal: Phys Chem Chem Phys; 2011 Mar 14; 13(10):4507-13. PubMed ID: 21258710.
    Abstract:
    We realize a biochemical filtering process by introducing a buffer in a biocatalytic signal-transduction logic system based on the function of an enzyme, esterase. The input, ethyl butyrate, is converted into butyric acid--the output signal, which in turn is measured by the drop in the pH value. The developed approach offers a versatile "network element" for increasing the complexity of biochemical information processing systems. Evaluation of an optimal regime for quality filtering is accomplished in the framework of a kinetic rate-equation model.
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