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  • Title: Changes in endogenous creatinine clearance in man on a controlled protein diet: effect of route of administration of a protein load.
    Author: Penner SB, Bernstein KN, Fine A.
    Journal: Clin Invest Med; 1990 Oct; 13(5):233-6. PubMed ID: 2125900.
    Abstract:
    Dietary protein has been implicated in the progressive decline in renal function seen in association with chronic renal failure. An acute protein load has been reported to increase creatinine clearance; however this alteration in function is variable. Therefore, the route of administration of a protein load was examined in this study while the dietary protein was controlled. Sequentially, both oral and intravenous protein loads were administered to the same volunteer while initially on a low protein diet (0.75 g/kg/24h) for three weeks followed by three weeks of an ad libitum protein diet (1.31 g/kg/24h). Neither the baseline serum creatinine nor the creatinine clearance were altered by the diet. Only the oral protein load resulted in an increase in the creatinine clearance. This study demonstrated that the route of administration, but not the dietary protein, is a determinant of the response of endogenous creatinine clearance to an acute protein load.
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