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  • Title: The role of bone fracture at the site of carcinogen exposure on nickel carcinogenesis in the soft tissue.
    Author: Ohmori T, Uraga N, Komi K, Tabei R, Shibata T.
    Journal: Jpn J Cancer Res; 1990 Dec; 81(12):1247-52. PubMed ID: 2125994.
    Abstract:
    The influence upon nickel subsulfide (alpha-Ni3S2; Ni-SS)-induced carcinogenesis in the soft tissue of bone fracture at the site of Ni-SS exposure was studied using female Fischer rats. During the one year of the experiment, the group subjected to bone fracture exhibited the shortest tumor induction time and survival time, and a significantly higher metastatic rate. The present study may suggest a model for the metastasis of human soft tissue tumors.
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