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  • Title: [Activity of the hypothalamic-pituitary-adrenal axis in patients with rheumatoid arthritis].
    Author: Imrich R.
    Journal: Vnitr Lek; 2010 Dec; 56(12):1271-3. PubMed ID: 21261114.
    Abstract:
    The controlled data accumulated so far support only subtle alterations in hypothalamic-pituitary-adrenal (HPA) axis function in rheumatoid arthritis (RA), mainly at the adrenal level, and particularly in a subset of premenopausal onset women. Consequences of the subtle HPA alterations in RA for the disease development remain unclear. From a broader perspective, the unresponsiveness of the HPA axis to chronic inflammation in RA can be simply considered an ongoing adaptation to chronic disease.
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