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  • Title: Plexiform fibrohistiocytic tumor with molecular and cytogenetic analysis.
    Author: Leclerc-Mercier S, Pedeutour F, Fabas T, Glorion C, Brousse N, Fraitag S.
    Journal: Pediatr Dermatol; 2011; 28(1):26-9. PubMed ID: 21261704.
    Abstract:
    A child with plexiform fibrohistiocytic tumor is presented, in whom a superficial biopsy was misdiagnosed as an inflammatory granuloma. Cytogenetic analysis revealed a 46,X,del(X)(q13)[3]/46,XX[23] karyotype. However, fluorescence in situ hybridization (FISH) and array-comparative genomic hybridization (CGH) analysis failed to detect any numerical or quantitative genomic anomaly. Because of lack of specific chromosomal hallmarks, a molecular diagnosis of plexiform fibrohistiocytic tumor with the currently available tools is not reliable.
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