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  • Title: Hepatotoxicity to different antituberculosis drug combinations.
    Author: Aziz S, Agha F, Hassan R, Fairoz SA, Hassan K.
    Journal: J Pak Med Assoc; 1990 Dec; 40(12):290-4. PubMed ID: 2126569.
    Abstract:
    Hepatotoxicity to different combinations of anti-tuberculosis drugs containing, Rifampicin (R), Streptomycin (S), Isoniazid (H), Pyrazinamide (Z) and Myambutol (E) is described in 47 patients who completed 6 to 9 months therapy. Seven cases (15%) showed signs of toxicity and in 4 patients (8.5%) the drugs had to be withdrawn. Two patients developed hepatitis, one with jaundice and the other with fever and deranged liver functions, while others 2 developed severe hypersensitivity reactions. Burning palms, difficulty in micturition, itching and giddiness were complained of by one patient each, which settled in due course without recourse to withdrawal of drugs.
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