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  • Title: Linker length dependent binding of a focal adhesion kinase derived peptide to the Src SH3-SH2 domains.
    Author: Lindfors HE, Venkata BS, Drijfhout JW, Ubbink M.
    Journal: FEBS Lett; 2011 Feb 18; 585(4):601-5. PubMed ID: 21266176.
    Abstract:
    The interaction between a peptide encompassing the SH3 and SH2 binding motifs of focal adhesion kinase (FAK) and the Src SH3-SH2 domains has been investigated with NMR spectroscopy and calorimetry. The binding to both motifs is anti-cooperative. Reduction of the long linker connecting the motifs does not lead to cooperativity. Short linkers that do not allow simultaneous intramolecular binding of the peptide to both motifs cause peptide-mediated dimerisation, even with a linker of only three amino acids. The role of the SH3 binding motif is discussed in view of the independent nature of the SH interactions.
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