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  • Title: [The combined action of N-methyl-N'-nitro-N-nitrosoguanidine and UV light on Bacillus subtilis].
    Author: Lotareva OV.
    Journal: Izv Akad Nauk SSSR Biol; 1990; (6):928-31. PubMed ID: 2127422.
    Abstract:
    The mutagenic interaction between ultraviolet irradiation and the alkylating agent N-methyl-N'-nitro-N-nitrosoguanidine was studied in repair-competent and excision-deficient strains of Bacillus subtilis. Pre-exposure to low doses of MNNG with following treatment by low and intermediate doses of UV light increase the resistance of Bac. subtilis to UV radiation (antagonistic effect). Probably pre-exposition with MNNG leads to induction of enzymes reparation, UV damages being controlled with adaptive response genes.
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