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  • Title: [Estimate of the dosage for radioiodine ablation of the thyroid gland in male Wistar rats].
    Author: Hanauer G, Schroth HJ.
    Journal: Zentralbl Veterinarmed A; 1990 Dec; 37(10):747-51. PubMed ID: 2127495.
    Abstract:
    The aim of this investigation was to determine the radioiodine dose necessary for the ablation of the thyroid gland in male Wistar rats. By a mathematical extrapolation of the kinetics of iodine-131, the radioisotope dose in the thyroid was calculated to be 467971 or 401540 rad after an intraperitoneal administration of 1 x 0.8 mCi (29.6 MBq) or 1 x 1.0 mCi (37.0 MBq) iodine-131, respectively. Because lower radioiodine activities did not result in a complete destruction of the thyroid (controlled by scintigraphic methods), it can be concluded that about 400,000 rad are necessary for the complete ablation of the thyroid gland by radioiodine.
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