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  • Title: Leber's hereditary optic neuropathy precipitated by tadalafil use for erectile dysfunction.
    Author: Cornish KS, Barras C.
    Journal: Semin Ophthalmol; 2011 Jan; 26(1):7-10. PubMed ID: 21275598.
    Abstract:
    Leber's hereditary optic neuropathy (LHON) is an inherited condition leading to bilateral centrocaecal scotoma. Phosphodiesterase type-5 (PDE5) inhibitors such as tadalafil are widely used for male erectile dysfunction. We present a case of a middle-aged male whose LHON presented acutely following tadalafil use. It is postulated that this is due to alteration in the optic nerve head perfusion.
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