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  • Title: Physical and biophysical properties of proton tracks of energies 1 keV to 300 MeV in water.
    Author: Liamsuwan T, Uehara S, Emfietzoglou D, Nikjoo H.
    Journal: Int J Radiat Biol; 2011 Feb; 87(2):141-60. PubMed ID: 21281230.
    Abstract:
    PURPOSE: To investigate physical and biophysical properties of proton tracks 1 keV-300 MeV using Monte Carlo track structure methods. MATERIALS AND METHODS: We present model calculations for cross sections and methods for simulations of full-slowing-down proton tracks. Protons and electrons were followed interaction-by-interaction to cut-off energies, considering elastic scattering, ionisation, excitation, and charge-transfer. RESULTS: Model calculations are presented for singly differential and total cross sections, and path lengths and stopping powers as a measure of the code evaluation. Depth-dose distributions for 160 MeV protons are compared with experimental data. Frequencies of energy loss by electron interactions increase from ∼ 3% for 10 keV to ∼ 77% for 300 MeV protons, and electrons deposit  >70% of the dose in 160 MeV tracks. From microdosimetry calculations, 1 MeV protons were found to be more effective than 5-300 MeV in energy depositions greater than 25, 50, and 500 eV in cylinders of diameters and lengths 2, 10, and 100 nm, respectively. For lower-energy depositions, higher-energy protons are more effective. Decreasing the target size leads to the reduction of frequency- and dose-mean lineal energies for protons <1 MeV, and conversely for higher-energy protons. CONCLUSIONS: Descriptions of proton tracks at molecular levels facilitate investigations of track properties, energy loss, and microdosimetric parameters for radiation biophysics, radiation therapy, and space radiation research.
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