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  • Title: [Detection and its clinical significance of IgM antibody in cerebrospinal fluid in patients with tuberculous meningitis].
    Author: Hu ZY.
    Journal: Zhonghua Jie He He Hu Xi Za Zhi; 1990 Oct; 13(5):299-301, 320. PubMed ID: 2128215.
    Abstract:
    Specific antibody for IgM in cerebrospinal fluid (CSF) of 45 patients with tuberculous meningitis (TBM), 33 patients with non-TBM and 51 control patients was determined by enzyme-linked immunosorbent assay, and compared with specific antibody for IgG. The sensitivity and specificity was 71.1% and 98.8% for IgM antibody, and 88.9% and 96.4% for IgG antibody respectively, but the positive rate of IgM antibody at early stage of TBM was higher than that of IgG antibody. There was a highly significant positive correlation between positive rates of the two types of antibody and contents of protein in CSF. The sensitivity and specificity was 97.8% and 98.8% respectively in detecting both the IgM and IgG antibodies in CSF simultaneously, which can be used as a supplementary method for the diagnosis of TBM.
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