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  • Title: [Diagnostic differentiation between precocious puberty and premature thelarche using ultrasonography and the stimulated LH/FSH quotient].
    Author: Pelzer V, Von Ditfurth M, Wendel U.
    Journal: Geburtshilfe Frauenheilkd; 1990 Dec; 50(12):964-8. PubMed ID: 2128288.
    Abstract:
    True precocious puberty represents a serious developmental disorder necessitating immediate therapeutic measures, whereas premature thelarche is a harmless variation from the norm. For the differential diagnosis the ultrasonographic evaluation of the internal genitalia is of value. Girls with precocious puberty reveal a statistically significantly greater uterus length and volume as well as ovarian size. The stimulated LH/FSH quotient allows verification of the diagnosis. This value is found always to be greater than 1 in precocious puberty and always less than 1 in premature thelarche.
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