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  • Title: Morphine inhibits TRH-induced intestinal transit increases.
    Author: Heitkemper MM, Bond EF.
    Journal: Peptides; 1990; 11(6):1113-7. PubMed ID: 2128399.
    Abstract:
    The current study examined the effects of intraperitoneal (IP) and intracisternal (IC) administration of the opiate agonist, morphine, and an opioid, central beta-endorphin, on thyrotropin releasing hormone (TRH)-induced small intestinal transit increases. Anesthetized rats, 14-day and older, were studied to determine age-related differences. Results showed that in all age groups IP morphine (2 mg/kg) blocked TRH (15 micrograms)-induced increases in transit of a charcoal bolus. Morphine 1 microgram and beta-endorphin 1 microgram administered IC in 0.6 microliter failed to block TRH (10 microgram)-induced increases in intestinal transit in 14-day-old rats. However both morphine and beta-endorphin 1 micrograms IC blocked TRH-induced increases in adult rats. Dose-response studies demonstrated that higher doses (greater than 1 microgram) of morphine IC were required to block TRH-induced increases in preweaning rats.
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