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  • Title: Comparative study of cefuroxime axetil and procaine penicillin in the treatment of uncomplicated gonorrhoea.
    Author: Kinghorn GR, Spencer RC, Smith TK, Woolley PD, Patel R, Robinson AJ.
    Journal: Int J STD AIDS; 1990 Jul; 1(4):285-7. PubMed ID: 2128472.
    Abstract:
    A total of 311 patients presenting with uncomplicated gonorrhoea were entered into a comparative randomized open-label study and given single-dose treatment with either oral cefuroxime axetil (CAE) or intramuscular procaine penicillin (PP). Neisseria gonorrhoeae was eliminated from 129 (98%) of 131 evaluable patients treated with CAE and 127 (98%) of 129 evaluable patients treated with PP. None of the 4 treatment failures (3 male and 1 female) were caused by beta-lactamase-producing isolates. Both treatments were well tolerated with minor adverse events reported in 3 (2%) of CAE treated patients. We conclude that CAE is an effective, well tolerated treatment for uncomplicated gonorrhoea which has the convenience and acceptability of single-dose oral therapy.
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