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  • Title: Semicarbazide-sensitive amine oxidase activity in rat aortic cultured smooth muscle cells.
    Author: Blicharski JR, Lyles GA.
    Journal: J Neural Transm Suppl; 1990; 32():337-9. PubMed ID: 2128506.
    Abstract:
    Metabolism of 5 microM benzylamine (BZ) by rat aortic cultured smooth muscle cells (SMC) is inhibited almost completely by 10(-3) M semicarbazide and 10(-6) M propargylamine, but is little affected by 10(-4) M and 10(-3) M pargyline and clorgyline, indicating BZ metabolism predominantly by the semicarbazide-sensitive amine oxidase (SSAO) previously characterized in rat aortic homogenates. Km values of 7-9 microM for BZ metabolism by SSAO in SMC cultures, indicate similar, if not identical properties, to the enzyme in the parent blood vessel.
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