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  • Title: A new method of total parenteral nutrition for surgical neonates: it is possible that cyclic TPN prevents intrahepatic cholestasis.
    Author: Takehara H, Hino M, Kameoka K, Komi N.
    Journal: Tokushima J Exp Med; 1990 Dec; 37(3-4):97-102. PubMed ID: 2128784.
    Abstract:
    Cholestasis associated with total parenteral nutrition (TPN) has been reported to be an incidence of 15% to 50% in surgical neonates. This study was designed to prevent the liver dysfunction, especially intrahepatic cholestasis, caused by TPN for surgical neonates. In the last three years, 10 surgical neonates ranged from 1868g to 3500g of birth weight have been treated by cyclic TPN that infuses solutions of TPN and Non-TPN alternately every four hours, because cyclic TPN may reduce an overloading for the liver by the compulsive and continuous TPN. Consequently, no hyperbilirubinemia and abnormal values of the serum transaminases were revealed in these neonates, and good results of nutritional supports were obtained by cyclic TPN. These results suggest that cyclic TPN is useful and safe in nutritional support for neonates, and cyclic TPN is much better than continuous TPN in order to prevent the liver dysfunction.
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