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  • Title: Comparative studies on Clostridium botulinum type A strains associated with infant botulism in Japan and in California, USA.
    Author: Tabita K, Sakaguchi S, Kozaki S, Sakaguchi G.
    Journal: Jpn J Med Sci Biol; 1990 Dec; 43(6):219-31. PubMed ID: 2129272.
    Abstract:
    Twenty strains of Clostridium botulinum type A associated with infant botulism cases, six in Japan and 14 in California, USA, were compared in their characters. All six Japanese strains produced medium-sized progenitor toxin (M toxin; Mr 300 k) but no hemagglutinin and showed lower 50% infective doses (ID50) in the infant mouse test; whereas most American strains produced large-sized progenitor toxin (L + LL toxins; Mr 500 k and 900 k) and hemagglutinin in addition to M toxin and showed higher ID50 in infant mice. No marked difference in the biochemical properties was found between the two groups except for two American strains.
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