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  • Title: [Intranuclear membranous inclusions in the CNS neurons of rats detectable after the administration of ascorbic acid and 6-hydroxydopamine].
    Author: Grigor'ev IP, Otellin VA.
    Journal: Tsitologiia; 1990; 32(12):1157-60. PubMed ID: 2129405.
    Abstract:
    Intranuclear membranous inclusions were found in neurons of the rat's cerebral cortex and caudate nucleus 2-21 days following the intraperitoneal injection of ascorbic acid (0.2 and 2.0 g/kg) or the intracisternal infusion of 6-hydroxydopamine (300 micrograms). The intranuclear inclusions were mostly round, occasionally irregular in shape, consisting of one or several concentric membranes; in addition, they were electron-lucid with the diameter of 0.2-0.5 microns, sometimes up to 1 micron. Possible relationship between the formation of intranuclear membranous inclusions and the acceleration of intranuclear metabolism, particularly lipid peroxidation processes, are discussed.
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