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  • Title: Severe respiratory distress syndrome unresponsive to intensive care treatment--diagnostic and therapeutic considerations.
    Author: Limbach HG, Hasenfus A, Bohle RM, Baghai A, Löffler G, Gortner L, Fries P, Meyer S.
    Journal: Klin Padiatr; 2011 Sep; 223(5):283-6. PubMed ID: 21294065.
    Abstract:
    Respiratory Distress Syndrome (RDS) is a common complication in preterm neonates. If RDS is not responding to conventional treatment modalities (surfactant therapy, ventilatory support, etc.), an underlying pathology (pulmonary lymphangiectasia, capillary alveolar dysplasia, alpha-1 antitrypsin deficiency, etc.) other then prematurity should be taken into consideration.Here, we report on a preterm neonate with the unusual simultaneous occurrence of pulmonary and systemic lymphangiectasia and homozygous alpha-1 antitrypsin deficiency who developed severe RDS that was refractory to conventional treatment. The diagnostic and therapeutic approach in this patient is presented.
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