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  • Title: Fos and jun: two into one will go.
    Author: Woodgett JR.
    Journal: Semin Cancer Biol; 1990 Dec; 1(6):389-97. PubMed ID: 2129427.
    Abstract:
    c-jun was the first oncogene to be identified as a transcription factor thus realizing the long-standing prediction that gene regulation plays a fundamental role in growth control. Not so predictable was that this protein is assisted in its function by a second proto-oncogene, c-fos; that the transcription factor they help comprise transducers hormonal signals; and that each are the archetypal members of gene families. Here, I describe the remarkable progress that has been made from the initial characterization of these oncogenes to our current understanding of their normal cellular function.
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