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  • Title: Production and characterization of monoclonal antibodies against tissue-type plasminogen activator.
    Author: Ding H, Wang JY, Song HY.
    Journal: Chin J Biotechnol; 1990; 6(3):223-7. PubMed ID: 2129498.
    Abstract:
    Four hybridoma clones, TA1, TA2, TA3 and TA4, producing monoclonal antibodies against t-PA were obtained by fusion of mouse myeloma cells (SP2/0 or NS-1) with mouse spleen cells previously immunized with purified t-PA. The antibody titers of the four hybridoma ascites were higher than 1 x 10(5) determined by ELISA. The double immune diffusion test showed that all hybridoma supernatants contained mouse IgG1. These monoclonal antibodies reacted only with t-PA, and rt-PA prepared by genetic engineering, but not with UK. t-PA, activity was inhibited by these monoclonal antibodies completely.
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