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  • Title: Emergence of raltegravir-resistant HIV-1 in the central nervous system.
    Author: Watanabe K, Honda M, Watanabe T, Tsukada K, Teruya K, Kikuchi Y, Oka S, Gatanaga H.
    Journal: Int J STD AIDS; 2010 Dec; 21(12):840-1. PubMed ID: 21297097.
    Abstract:
    Integrase inhibitor-resistant HIV-1 was detected in the cerebrospinal fluid, but not in the plasma of a 42-year-old man with HIV encephalopathy treated with a raltegravir (RAL)-containing regimen. Raltegravir resistance may develop in the central nervous system when the virus is already multi-drug resistant because of different penetration into cerebrospinal fluid of individual antiretroviral agents.
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