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  • Title: A facile route to polysubstituted indoles via three-component reaction of 2-ethynylaniline, sulfonyl azide, and nitroolefin.
    Author: Chen Z, Zheng D, Wu J.
    Journal: Org Lett; 2011 Mar 04; 13(5):848-51. PubMed ID: 21299243.
    Abstract:
    A copper-catalyzed three-component reaction of 2-ethynylaniline, sulfonyl azide, and nitroolefin is reported. This reaction generates functionalized indoles in good yields and proceeds smoothly under mild conditions. Some hits as an HCT-116 inhibitor are found from the preliminary biological screening.
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