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  • Title: Effects of prolonged warm and cold ischemia in a solitary kidney animal model after partial nephrectomy: an ultrastructural investigation.
    Author: Tyritzis SI, Zachariades M, Evangelou K, Gorgoulis VG, Kyroudi-Voulgari A, Pavlakis K, Troupis TG, Constantinides CA.
    Journal: Ultrastruct Pathol; 2011 Apr; 35(2):60-5. PubMed ID: 21299345.
    Abstract:
    Ischemia-reperfusion injury can be detrimental to the solitary kidney, especially when it is accompanied by ablation. To the authors' knowledge, the effects of partial nephrectomy with prolonged application of ischemia have never been described at the ultrastructural level. Therefore, the authors used an animal model and focused on putative structural effects in the glomerular basement membrane and the podocytes. They demonstrate the advantageous role of cold ischemia, even in up to 120 min. In contrast, more than 60 min of warm ischemia leads to catastrophic lesions in all the cellular structures, as is reflected by mortality due to acute renal failure.
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