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Pubmed for Handhelds

PUBMED FOR HANDHELDS

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  • Title: Primary subcutaneous Alternaria alternata infection of the hand in an immunocompromised host.
    Author: Kpodzo DS, Calderwood MS, Ruchelsman DE, Abramson JS, Piris A, Winograd JM, Kotton CN.
    Journal: Med Mycol; 2011 Jul; 49(5):543-7. PubMed ID: 21299373.
    Abstract:
    We describe a case of a progressive subcutaneous Alternaria alternata infection in the hand of a patient with chronic lymphocytic leukemia (CLL). The diagnosis was based upon the examination of tissue biopsy and isolation of the etiologic agent in culture. The identity of the isolate was determined by phenotypic characteristics and by sequencing the ITS and D1/D2 regions of the rDNA. Despite combination therapy with voriconazole and micafungin, the lesion continued to progress. Posaconazole therapy, along with surgical excision of the infected tissue, resulted in the eradication of infection. The limitations of the clinical management of invasive Alternaria infections are discussed.
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