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  • Title: Suicide inactivation of tyrosinase in its action on tetrahydropterines.
    Author: Muñoz-Muñoz JL, Garcia-Molina F, Arribas E, Garcia-Ruíz PA, Tudela J, Garcia-Cánovas F, Rodríguez-López JN.
    Journal: J Enzyme Inhib Med Chem; 2011 Oct; 26(5):728-33. PubMed ID: 21299451.
    Abstract:
    Tetrahydrobiopterin (BH(4)), methyl-tetrahydropterin (MBH(4)) and dimethyl-tetrahydropterin (DMBH(4)) are oxidized by tyrosinase in a process during which the suicide inactivation of tyrosinase may occur. From the kinetic study of this process, [Formula: see text] (apparent maximum constant for the suicide inactivation), [Formula: see text] (Michaelis constant for the substrate) and r (number of turnovers that the enzyme makes before the inactivation) can be obtained. From the results obtained, it can be deduced that the velocity of the inactivation governed by ([Formula: see text]) and the potency of the same ([Formula: see text]) follow the order: BH(4) > MBH(4) > DMBH(4).
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