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  • Title: Hepatocellular carcinoma metastatic to the orbit: a case report.
    Author: Oida Y, Ohtani Y, Dowaki S, Tobita K, Mukai M, Abe Y, Nakamura M, Imaizumi T, Makuuchi H.
    Journal: Tokai J Exp Clin Med; 2006 Apr 20; 31(1):7-10. PubMed ID: 21302214.
    Abstract:
    Hepatocellular carcinoma rarely metastasizes to the orbit. We report on a 72-year-old man with a past history of resection for hepatocellular carcinoma and recurrent HCC, who presented with diplopia and left painful proptosis. Head scans revealed a large and irregular mass in the left orbit that caused destruction of the orbital bone superiorly and posterolaterally. A biopsy specimens of the orbital tumor showed features of metastatic foci of hepatocellular carcinoma. The tumor was surgically excised and histological findings revealed moderately differentiated hepatocellular carcinoma, resembling hepatocytes with a tendency to form trabeculae. Immunohistochemically, the tumor cells showed positive reaction against low-molecular-weight keratin and α-fetoprotein. There have been only 12 previous cases of hepatocellular carcinoma metastatic to the orbit cited in the literature. We presented here a rare case of hepatocellular carcinoma metastatic to the orbit.
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