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  • Title: Claurailas A-D, cytotoxic carbazole alkaloids from the roots of Clausena harmandiana.
    Author: Songsiang U, Thongthoom T, Boonyarat C, Yenjai C.
    Journal: J Nat Prod; 2011 Feb 25; 74(2):208-12. PubMed ID: 21302964.
    Abstract:
    Four new carbazole alkaloids, claurailas A-D (1-4), as well as 12 known carbazoles and three known coumarins were isolated from the roots of Clausena harmandiana. Heptaphylline (6) and 7-methoxyheptaphylline (7) showed strong cytotoxicity against NCI-H187 and KB cell lines with IC(50) values ranging from 1.3 to 2.7 μM. Compound 7 showed no cytotoxicity against Vero cells.
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