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  • Title: Fibrinogen Geneva, a new case of A alpha 16 Arg----Cys dysfibrinogenaemia.
    Author: Furlan M, Bögli C, Hofer A, Bouvier CA, de Moerloose P.
    Journal: Blood Coagul Fibrinolysis; 1990 Jun; 1(2):139-43. PubMed ID: 2130925.
    Abstract:
    A new congenital variant of fibrinogen, from which only half the normal amount of fibrinopeptide A can be released by thrombin, was found in three members of a family having no major bleeding or thrombotic tendency. Following carboxamidomethylation of the reduced fibrinogen chains, an abnormal peptide was cleaved by thrombin from the amino terminus of the A alpha-chain (A* alpha 1-19) and isolated by reversed phase high-performance liquid chromatography. Amino acid analysis indicated the presence of carboxymethyl cysteine in this A alpha-chain fragment which in normal fibrinogen is devoid of cysteine. We conclude that fibrinogen Geneva is another fibrinogen variant with the substitution A alpha 16 Arg----Cys.
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