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  • Title: Strong association between the -308 TNF promoter polymorphism and allergic rhinitis in Pakistani patients.
    Author: Minhas K, Micheal S, Ahmed F, Ahmed A.
    Journal: J Investig Allergol Clin Immunol; 2010; 20(7):563-6. PubMed ID: 21313996.
    Abstract:
    BACKGROUND: Allergic rhinitis (AR) is a common complex allergic inflammatory disorder. The tumor necrosis factor (TNF) alpha polymorphism G-308A is present in the promoter region of the gene and considered to be important due to its role in different allergic diseases. OBJECTIVES: We aimed to identify genetic associations between this polymorphism and AR in patients of Pakistani origin. METHODS: We analyzed the distribution of G-308A in 153 unrelated AR patients and 116 unrelated healthy controls. Samples were genotyped for G-308A using restriction fragment length polymorphism. RESULTS: The TNF -308A allele (TNF2) was significantly more frequent in patients with AR (37%) than in controls (16%, P<.001; chi2=32.15). Genotype distribution was also significantly different between patients and controls (P<.001; chi2=40.81). The TNF2 homozygous genotype and TNF1/2 heterozygous genotype were significantly more common in AR patients (TNF2, 12%; TNF1/2, 49%) than in controls (TNF2, 4%; TNF1/2, 23%), whereas the normal TNF1 homozygous genotype was more frequent in controls (73%) than in patients (39%). CONCLUSION: Our results suggest a strong association between the promoter polymorphism of TNF-alpha and AR in Pakistani cohorts.
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