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  • Title: Automated preparation of Re-188 lipiodol for the treatment of hepatocellular carcinoma.
    Author: Uccelli L, Pasquali M, Boschi A, Giganti M, Duatti A.
    Journal: Nucl Med Biol; 2011 Feb; 38(2):207-13. PubMed ID: 21315276.
    Abstract:
    The iodinated oil lipiodol is commonly used as a carrier for in situ delivery of drugs or radioactivity to hepatic tumors. Recently, we reported a new kit formulation for high-activity labeling of lipiodol with the β-emitting radionuclide Re-188. Since the whole preparation involves different steps and complex manipulations of high-activity samples, we describe here an automated synthesis module that allows the easy preparation of sterile and pyrogen-free samples of Re-188 lipiodol ready to be administered to the patient. Important advantages include the possibility to incorporate high Re-188 activity into the lipiodol hydrophobic phase and a sharp reduction of radiation exposure of the operator assisting the labelling procedure. Application of this modular reaction system could be also extended to the preparation of other Re-188 radiopharmaceuticals and to compound labelled with different β-emitting therapeutic radionuclides.
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